In 1947 the FDA approved methamphetamine for obesity. https://www.ahajournals.org/doi/10.1161/circulationaha.111.028381

Methamphetamine, under the brand name Desoxyn is currently approved by the FDA for ADHD. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/005378s034lbl.pdf