Thanks Rob, for the deep dive into this fascinating topic.

While I haven't done a formal analysis on this, in my years of reading studies on medication treatments for depression, I had the distinct impression that on average, American-conducted studies showed far higher rates of side effects - both in those given medication and the placebo groups, than did subjects taking the same substances in European studies. Depressed Americans seem to endorse headaches, sexual difficulties, nausea, vertigo, fatigue, and insomnia far more often than depressed Europeans do.

I've wondered whether this was primarily due to expectations about the power of medications, or whether there was some difference in how the questions were being asked, or social expectations about how much complaining one shares with a doctor.